College football odds, picks, predictions for Week 2, 2024: Proven model backs Oklahoma in best bets (2024)

The first top-10 matchup of the 2024 college football season takes place during the Week 2 college football schedule when No. 9 Michigan hosts No. 4 Texas on Saturday afternoon. Michigan is the defending national champion and is coming off a 30-10 win over Fresno State, but Texas is a 6.5-point favorite in the Week 2 college football odds via SportsLine consensus. The Longhorns, led by junior quarterback Quinn Ewers, are coming off a 52-0 win over Colorado State in Week 1. Should you back them as road favorites with your Week 2 college football bets?

The other ranked vs. ranked matchup in Week 2 features No. 24 NC State vs. No. 15 Tennessee (-7.5) in Charlotte on Saturday night. Tennessee opened as 4-point favorite in the Week 2 college football spreads, but the line has moved toward the Vols following their 69-3 win over Chattanooga. Before locking in any college football picks for Week 2 of the 2024 season, be sure to see the latest college football predictions from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

Now, it has turned its attention to the latest college football oddsand Week 2college football betting lines on the spread, money line, and over/under.Head here to see every pick.

Top college football predictions for Week 2

One of the college football picks the model is high on during Week 2: South Carolina (+9.5) covers against Kentucky at 3:30 p.m. ET on Saturday. The Gameco*cks erased a fourth-quarter deficit against Old Dominion last week, as freshman quarterback LaNorris Sellers scored a late rushing touchdown. His passing numbers were mediocre, but that game allowed him to settle in as he made his college debut.

Senior running back Raheim Sanders rushed for 88 yards and a touchdown in his first game with South Carolina after transferring from Arkansas, while Sellers added 68 rushing yards. Kentucky is coming off a long evening against Southern Miss, as the game was delayed for more than two hours due to lightning before ultimately getting called for good in the third quarter after a second delay. The Wildcats have only covered the spread once in their last six games against SEC teams, and South Carolina is covering in over 60% of the model's latest simulations. See the rest of its Week 2 college football picks here.

Another prediction: No. 16 Oklahoma (-28.5) easily covers the huge spread against Houston in a 7:45 p.m. ET kickoff on Saturday. The Sooners are coming off an impressive season opener, as they rolled to a 51-3 win over Temple as 42.5-point favorites. Sophom*ore quarterback Jackson Arnold threw for 141 yards and four touchdowns before getting to rest down the stretch of that game.

Oklahoma rushed for 220 yards and a touchdown on 36 carries, averaging 6.1 yards per attempt. Meanwhile, Houston's offense managed just seven points in a 20-point loss to UNLV in Willie Fritz's first game as head coach. The model does not expect Houston to look any better this week, as Oklahoma is covering the large spread in well over 60% of simulations. See picks for every other game in Week 2 here.

How to make college football picks for Week 2

The model has also made the call on who wins and covers in every FBS matchup in Week 2, and it's calling for multiple underdogs to win outright.You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $2,000 in profit since its inception, and find out.

College football odds for Week 2

See full Week 2 college football picks, odds, predictions here

Friday, Sept. 6

BYU at SMU (-11, 55)

Duke at Northwestern (-3, 38.5)

Saturday, Sept. 7

Texas at Michigan (+6.5, 45)

Bowling Green at Penn State (-33, 49.5)

Arkansas at Oklahoma State (-8, 60)

Kansas State at Tulane (+10, 49.5)

South Carolina at Kentucky (-9.5, 45)

Iowa State at Iowa (-3, 36)

Michigan State at Maryland (-9.5, 44)

Virginia at Wake Forest (-2, 54)

South Florida at Alabama (-31, 64.5)

Kansas at Illinois (+5.5, 55.5)

Western Michigan at Ohio State (-39, 54)

Colorado at Nebraska (-7.5, 57.5)

Houston at Oklahoma (-29.5, 52.5)

Appalachian State at Clemson (-16.5, 52)

Boise State at Oregon (-18, 61)

Texas Tech at Washington State (-1, 65.5)

Mississippi State at Arizona State (-7, 56.5)

Utah State at USC (-28, 61.5)

College football odds, picks, predictions for Week 2, 2024: Proven model backs Oklahoma in best bets (2024)
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